Wrinkle relaxers like Botox have long been a go-to for smoothing expression lines and maintaining a youthful appearance. But with newer options like Daxxify and Letybo available, you may be wondering if it’s time to switch things up.
At Integrated Aesthetics, our expert injectors help patients choose the right wrinkle relaxer based on their goals, facial anatomy, and lifestyle every day. Here’s what to consider if you’re thinking about making a change.
How Do Wrinkle Relaxers Like Botox, Dysport, Jeuveau, and Daxxify Compare?
All wrinkle relaxers are neuromodulators that temporarily soften dynamic wrinkles by relaxing the underlying facial muscles, and most last around 3-4 months:
- Botox is the most well-known and has decades of clinical use behind it. It works well for forehead lines, crow’s feet, and frown lines.
- Dysport spreads slightly more than Botox, making it a good option for treating larger areas like the forehead.
- Xeomin is a “naked” neurotoxin, meaning it contains no accessory proteins. This may be beneficial if you’ve developed a tolerance to other formulas.
- Daxxify hit the market in late 2022, promising to have longer-lasting results for some patients.
- Jeuveau is sometimes called “Newtox” and has been popular among patients looking for a Botox alternative.
They each have subtle differences, which may or may not be noticeable to you. Much of the differences depend on how your injector uses the toxins, such as with dosing choices and injection areas.
If you’re happy with your current results, there’s no need to switch. But if you’re looking for longer-lasting effects, faster onset, or have noticed a decrease in your results over time, it might be worth exploring your options.
What About Letybo—Is It Worth a Try?
Letybo is a new botulinum toxin that has just entered the U.S. market with the promise of offering somewhat lower-cost treatments. While it’s exciting to see innovation in the neuromodulator space, Letybo has not yet demonstrated any meaningful differences from well-established products like Botox or Dysport in terms of onset, longevity, or efficacy.
At Integrated Aesthetics, we’re keeping an eye on Letybo as more clinical data becomes available and as it rolls out to more practices. For now, we continue to recommend wrinkle relaxers with a longer track record of safety and consistent performance.
How Today’s Neuromodulators Compare
| Product | Key Distinction | Typical Longevity* | Why We Might Recommend It |
| Botox (onabotulinumtoxinA) ** | Industry gold standard with the most extensive safety data | ~3–4 months | Reliable, versatile results for virtually any dynamic line |
| Dysport (abobotulinumtoxinA) ** | Spreads slightly more, ideal for broad areas | ~3–4 months | Smoother forehead coverage with fewer injection points |
| Xeomin (incobotulinumtoxinA) ** | “Naked” toxin—no accessory proteins | ~3–4 months | Great for patients who may have developed antibody‑related tolerance |
| Daxxify (daxibotulinumtoxinA‑lanm) ** | First peptide‑stabilized neuromodulator; results can last 6 months | ~3–6 months | Ideal for patients who want to reduce visit frequency |
| Jeuveau (prabotulinumtoxinA) | Marketed as “#Newtox” with quick onset | ~3–4 months | |
| Letybo (letibotulinumtoxinA‑wlbg) | Newest option just hitting the market | ~3–4 months |
*Longevity varies based on dosage, individual metabolism, and treatment area.
**Formulas preferred by the Integrated Aesthetics team.
Signs It Might Be Time to Try a Different Wrinkle Relaxer
Not sure if your current treatment is still the best fit? Here are a few signs that switching could be beneficial:
- Shorter‑than‑usual longevity. If your results fade after only 6–8 weeks, your body may be metabolizing the product faster—or you may have developed antibodies against its complexing proteins.
- Dose creep. Needing noticeably higher units each session can indicate emerging resistance or an imprecise dosing technique from another medical spa.
- Scheduling fatigue. Patients balancing work, travel, and family often prefer Daxxify’s potential 6‑month span to quarterly touch‑ups. Note that each patient metabolizes each product on a unique timeline, so be sure to try Daxxify first before relying on it for 6 months of results.
- Skin thickness changes. As we age, deeper creases may warrant a product with a wider spread or a complementary filler.
- Plain old curiosity. Some patients simply enjoy comparing how each formula “feels” or looks on their unique anatomy, leading them to try a newer product like Dysport or Daxxify.
Can You Develop Resistance to Botox?
In rare cases, patients may develop a resistance to Botox due to the formation of neutralizing antibodies. This is more common with frequent or high-dose treatments. If you’ve noticed your usual results diminishing despite consistent technique and dosing, switching to a product like Xeomin (which lacks complexing proteins) may help restore effectiveness.
That said, most patients do not develop resistance, and changes in results are more often related to dosing, injection technique, or lifestyle factors. That’s why it’s so important to work with experienced injectors who understand the nuances of each product!
“Dr.Chiang and her staff listen to all my concerns and I always feel we’re on the same page when I go in for my treatments. I’ve had Botox throughout my forehead, eleven lines, crows feet, and Juveaderm in my lips. I bruise easily so I’ve had horrible bruises in the past from OTHER injectors that lasted a week or more but with Dr.Chiang it’s always gone within a day or so. 10/10 would recommend her for all your cosmetic needs!”
How We Help You Choose the Right Neurotoxin
At Integrated Aesthetics, we customize every injectable treatment plan. Whether you’re seeing board-certified dermatologist Dr. Melissa Chiang or a highly trained aesthetic nurse, we evaluate:
- Muscle mass & symmetry (Are your corrugator muscles overpowering a standard dose?)
- Line depth & skin quality (Would combining a wrinkle relaxer with a resurfacing laser or dermal filler serve you better?)
- Treatment history (How long did previous products last? Any side effects?)
- Lifestyle & scheduling needs (Do you prefer quarterly maintenance or twice‑a‑year visits?)
Your injector may recommend a “test drive” of a different FDA-approved toxin, tweak your dose, or pair your wrinkle relaxer with energy‑based skin tightening to enhance results. Because our practice offers dermatology, cosmetic surgery, and medspa services under one roof, your recommended treatment plan is truly integrated.
If you’re wondering whether a different wrinkle relaxer could give you better results, or if you’re simply curious about the newer products on the market, schedule a consultation at Integrated Aesthetics!
Our medspa team is highly qualified to help you determine whether switching from Botox makes sense for you and create a personalized treatment plan to match your goals. Call us today at (281) 404-5454 to book your appointment!
